Inflammation is not only a protective mechanism during tissue injury, but also has a key role in tissue repair.Cytokines and growth factors which are released during inflammation are critical for tissue repair and one of the well-known angiogenic factors is vascular endothelial growth factor. Angiogenesis involves endothelial cells as well as INFLAMMATORY cells which release several angiogenic factors. Hypoxia is the most important stimulator for inflammation and angiogenesis. Some of the INFLAMMATORY MEDIATORS are directly and/or indirectly alter angiogenesis and on the other hand, some of angiogenic factors have INFLAMMATORY effects. Therefore, it seems that there is a close relationship between angiogenesis and inflammation. This review evaluated the relationship between inflammation and angiogenesis and the role of INFLAMMATORY cells and MEDIATORS in angiogenesis process.

Background: INFLAMMATORY MEDIATORS are an important component in the pathophysiology of the coronavirus disease 2019 (COVID-19). This study aimed to assess the effects of reducing INFLAMMATORY MEDIATORS using hemoperfusion (HP) and continuous renal replacement therapy (CRRT) on the mortality of patients with COVID-19. Materials and Methods: Twelve patients with confirmed diagnosis of COVID19 were included. All patients had acute respiratory distress syndrome (ARDS). Patients were divided into three groups, namely, HP, CRRT and HP+CRRT. The primary outcome was mortality and the secondary outcomes were oxygenation and reduction in INFLAMMATORY MEDIATORS at the end of the study. Results: Patients were not different at baseline in demographics, INFLAMMATORY cytokine levels, and the level of acute phase reactants. Half of the patients (3 out of 6) in the HP+CRRT group survived along with the survival of one patient (1 out of 2) in the HP group. All four patients in the CRRT group died. Serum creatinine (SCr), Interleukin-1 (IL1), Interleukin-6 (IL6), Interleukin-8 (IL8), partial pressure of oxygen (PaO2), O2 saturation (O2 sat), and hemodynamic parameters improved over time in HP+CRRT and CRRT groups, but no significant difference was observed in the HP group (All Ps > 0. 05). Conclusion: Combined HP and CRRT demonstrated the best result in terms of mortality, reduction of INFLAMMATORY MEDIATORS and oxygenation. Further investigations are needed to explore the role of HP+CRRT in COVID-19 patients.